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NEDD4L Is Downregulated in Colorectal Cancer and Inhibits Canonical WNT Signaling
The NEDD4 family of E3 ubiquitin ligases includes nine members. Each is a modular protein, containing an N-terminal C2 domain for cell localization, two-to-four central WW domains for substrate recognition, and a C-terminal, catalytic HECT domain, which is responsible for catalyzing the ubiquitylati...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842946/ https://www.ncbi.nlm.nih.gov/pubmed/24312311 http://dx.doi.org/10.1371/journal.pone.0081514 |