PKCε Signalling Activates ERK1/2, and Regulates Aggrecan, ADAMTS5, and miR377 Gene Expression in Human Nucleus Pulposus Cells

The protein kinase C (PKC) signaling, a major regulator of chondrocytic differentiation, has been also implicated in pathological extracellular matrix remodeling, and here we investigate the mechanism of PKCε-dependent regulation of the chondrocytic phenotype in human nucleus pulposus (NP) cells der...

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Detalles Bibliográficos
Autores principales: Tsirimonaki, Emmanouella, Fedonidis, Constantinos, Pneumaticos, Spiros G., Tragas, Adamantios A., Michalopoulos, Ioannis, Mangoura, Dimitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842981/
https://www.ncbi.nlm.nih.gov/pubmed/24312401
http://dx.doi.org/10.1371/journal.pone.0082045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842981/
https://www.ncbi.nlm.nih.gov/pubmed/24312401
http://dx.doi.org/10.1371/journal.pone.0082045

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