Hdac6 regulates Tip60-p400 function in stem cells

In embryonic stem cells (ESCs), the Tip60 histone acetyltransferase activates genes required for proliferation and silences genes that promote differentiation. Here we show that the class II histone deacetylase Hdac6 co-purifies with Tip60-p400 complex from ESCs. Hdac6 is necessary for regulation of...

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Detalles Bibliográficos
Autores principales: Chen, Poshen B, Hung, Jui-Hung, Hickman, Taylor L, Coles, Andrew H, Carey, James F, Weng, Zhiping, Chu, Feixia, Fazzio, Thomas G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843111/
https://www.ncbi.nlm.nih.gov/pubmed/24302573
http://dx.doi.org/10.7554/eLife.01557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843111/
https://www.ncbi.nlm.nih.gov/pubmed/24302573
http://dx.doi.org/10.7554/eLife.01557

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