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Relationships among Smoking Habits, Airflow Limitations, and Metabolic Abnormalities in School Workers
BACKGROUND: Chronic obstructive pulmonary disease is caused mainly by habitual smoking and is common among elderly individuals. It involves not only airflow limitation but also metabolic disorders, leading to increased cardiovascular morbidity and mortality. OBJECTIVE: We evaluated relationships amo...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843673/ https://www.ncbi.nlm.nih.gov/pubmed/24312268 http://dx.doi.org/10.1371/journal.pone.0081145 |
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author | Horie, Masafumi Noguchi, Satoshi Tanaka, Wakae Goto, Yasushi Yoshihara, Hisanao Kawakami, Masaki Suzuki, Masaru Sakamoto, Yoshio |
author_facet | Horie, Masafumi Noguchi, Satoshi Tanaka, Wakae Goto, Yasushi Yoshihara, Hisanao Kawakami, Masaki Suzuki, Masaru Sakamoto, Yoshio |
author_sort | Horie, Masafumi |
collection | PubMed |
description | BACKGROUND: Chronic obstructive pulmonary disease is caused mainly by habitual smoking and is common among elderly individuals. It involves not only airflow limitation but also metabolic disorders, leading to increased cardiovascular morbidity and mortality. OBJECTIVE: We evaluated relationships among smoking habits, airflow limitation, and metabolic abnormalities. METHODS: Between 2001 and 2008, 15,324 school workers (9700 males, 5624 females; age: ≥30 years) underwent medical checkups, including blood tests and spirometry. They also responded to a questionnaire on smoking habits and medical history. RESULTS: Airflow limitation was more prevalent in current smokers than in ex-smokers and never-smokers in men and women. The frequency of hypertriglyceridemia was higher in current smokers in all age groups, and those of low high-density-lipoprotein cholesterolemia and diabetes mellitus were higher in current smokers in age groups ≥ 40 s in men, but not in women. There were significant differences in the frequencies of metabolic abnormalities between subjects with airflow limitations and those without in women, but not in men. Smoking index was an independent factor associated with increased frequencies of hypertriglyceridemia (OR 1.015; 95% CI: 1.012–1.018; p<0.0001) and low high-density-lipoprotein cholesterolemia (1.013; 1.010–1.016; p<0.0001) in men. Length of smoking cessation was an independent factor associated with a decreased frequency of hypertriglyceridemia (0.984; 0.975–0.994; p = 0.007). CONCLUSIONS: Habitual smoking causes high incidences of airflow limitation and metabolic abnormalities. Women, but not men, with airflow limitation had higher frequencies of metabolic abnormalities. |
format | Online Article Text |
id | pubmed-3843673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38436732013-12-05 Relationships among Smoking Habits, Airflow Limitations, and Metabolic Abnormalities in School Workers Horie, Masafumi Noguchi, Satoshi Tanaka, Wakae Goto, Yasushi Yoshihara, Hisanao Kawakami, Masaki Suzuki, Masaru Sakamoto, Yoshio PLoS One Research Article BACKGROUND: Chronic obstructive pulmonary disease is caused mainly by habitual smoking and is common among elderly individuals. It involves not only airflow limitation but also metabolic disorders, leading to increased cardiovascular morbidity and mortality. OBJECTIVE: We evaluated relationships among smoking habits, airflow limitation, and metabolic abnormalities. METHODS: Between 2001 and 2008, 15,324 school workers (9700 males, 5624 females; age: ≥30 years) underwent medical checkups, including blood tests and spirometry. They also responded to a questionnaire on smoking habits and medical history. RESULTS: Airflow limitation was more prevalent in current smokers than in ex-smokers and never-smokers in men and women. The frequency of hypertriglyceridemia was higher in current smokers in all age groups, and those of low high-density-lipoprotein cholesterolemia and diabetes mellitus were higher in current smokers in age groups ≥ 40 s in men, but not in women. There were significant differences in the frequencies of metabolic abnormalities between subjects with airflow limitations and those without in women, but not in men. Smoking index was an independent factor associated with increased frequencies of hypertriglyceridemia (OR 1.015; 95% CI: 1.012–1.018; p<0.0001) and low high-density-lipoprotein cholesterolemia (1.013; 1.010–1.016; p<0.0001) in men. Length of smoking cessation was an independent factor associated with a decreased frequency of hypertriglyceridemia (0.984; 0.975–0.994; p = 0.007). CONCLUSIONS: Habitual smoking causes high incidences of airflow limitation and metabolic abnormalities. Women, but not men, with airflow limitation had higher frequencies of metabolic abnormalities. Public Library of Science 2013-11-29 /pmc/articles/PMC3843673/ /pubmed/24312268 http://dx.doi.org/10.1371/journal.pone.0081145 Text en © 2013 Horie et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Horie, Masafumi Noguchi, Satoshi Tanaka, Wakae Goto, Yasushi Yoshihara, Hisanao Kawakami, Masaki Suzuki, Masaru Sakamoto, Yoshio Relationships among Smoking Habits, Airflow Limitations, and Metabolic Abnormalities in School Workers |
title | Relationships among Smoking Habits, Airflow Limitations, and Metabolic Abnormalities in School Workers |
title_full | Relationships among Smoking Habits, Airflow Limitations, and Metabolic Abnormalities in School Workers |
title_fullStr | Relationships among Smoking Habits, Airflow Limitations, and Metabolic Abnormalities in School Workers |
title_full_unstemmed | Relationships among Smoking Habits, Airflow Limitations, and Metabolic Abnormalities in School Workers |
title_short | Relationships among Smoking Habits, Airflow Limitations, and Metabolic Abnormalities in School Workers |
title_sort | relationships among smoking habits, airflow limitations, and metabolic abnormalities in school workers |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843673/ https://www.ncbi.nlm.nih.gov/pubmed/24312268 http://dx.doi.org/10.1371/journal.pone.0081145 |
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