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Relationships among Smoking Habits, Airflow Limitations, and Metabolic Abnormalities in School Workers

BACKGROUND: Chronic obstructive pulmonary disease is caused mainly by habitual smoking and is common among elderly individuals. It involves not only airflow limitation but also metabolic disorders, leading to increased cardiovascular morbidity and mortality. OBJECTIVE: We evaluated relationships amo...

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Autores principales: Horie, Masafumi, Noguchi, Satoshi, Tanaka, Wakae, Goto, Yasushi, Yoshihara, Hisanao, Kawakami, Masaki, Suzuki, Masaru, Sakamoto, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843673/
https://www.ncbi.nlm.nih.gov/pubmed/24312268
http://dx.doi.org/10.1371/journal.pone.0081145
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author Horie, Masafumi
Noguchi, Satoshi
Tanaka, Wakae
Goto, Yasushi
Yoshihara, Hisanao
Kawakami, Masaki
Suzuki, Masaru
Sakamoto, Yoshio
author_facet Horie, Masafumi
Noguchi, Satoshi
Tanaka, Wakae
Goto, Yasushi
Yoshihara, Hisanao
Kawakami, Masaki
Suzuki, Masaru
Sakamoto, Yoshio
author_sort Horie, Masafumi
collection PubMed
description BACKGROUND: Chronic obstructive pulmonary disease is caused mainly by habitual smoking and is common among elderly individuals. It involves not only airflow limitation but also metabolic disorders, leading to increased cardiovascular morbidity and mortality. OBJECTIVE: We evaluated relationships among smoking habits, airflow limitation, and metabolic abnormalities. METHODS: Between 2001 and 2008, 15,324 school workers (9700 males, 5624 females; age: ≥30 years) underwent medical checkups, including blood tests and spirometry. They also responded to a questionnaire on smoking habits and medical history. RESULTS: Airflow limitation was more prevalent in current smokers than in ex-smokers and never-smokers in men and women. The frequency of hypertriglyceridemia was higher in current smokers in all age groups, and those of low high-density-lipoprotein cholesterolemia and diabetes mellitus were higher in current smokers in age groups ≥ 40 s in men, but not in women. There were significant differences in the frequencies of metabolic abnormalities between subjects with airflow limitations and those without in women, but not in men. Smoking index was an independent factor associated with increased frequencies of hypertriglyceridemia (OR 1.015; 95% CI: 1.012–1.018; p<0.0001) and low high-density-lipoprotein cholesterolemia (1.013; 1.010–1.016; p<0.0001) in men. Length of smoking cessation was an independent factor associated with a decreased frequency of hypertriglyceridemia (0.984; 0.975–0.994; p = 0.007). CONCLUSIONS: Habitual smoking causes high incidences of airflow limitation and metabolic abnormalities. Women, but not men, with airflow limitation had higher frequencies of metabolic abnormalities.
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spelling pubmed-38436732013-12-05 Relationships among Smoking Habits, Airflow Limitations, and Metabolic Abnormalities in School Workers Horie, Masafumi Noguchi, Satoshi Tanaka, Wakae Goto, Yasushi Yoshihara, Hisanao Kawakami, Masaki Suzuki, Masaru Sakamoto, Yoshio PLoS One Research Article BACKGROUND: Chronic obstructive pulmonary disease is caused mainly by habitual smoking and is common among elderly individuals. It involves not only airflow limitation but also metabolic disorders, leading to increased cardiovascular morbidity and mortality. OBJECTIVE: We evaluated relationships among smoking habits, airflow limitation, and metabolic abnormalities. METHODS: Between 2001 and 2008, 15,324 school workers (9700 males, 5624 females; age: ≥30 years) underwent medical checkups, including blood tests and spirometry. They also responded to a questionnaire on smoking habits and medical history. RESULTS: Airflow limitation was more prevalent in current smokers than in ex-smokers and never-smokers in men and women. The frequency of hypertriglyceridemia was higher in current smokers in all age groups, and those of low high-density-lipoprotein cholesterolemia and diabetes mellitus were higher in current smokers in age groups ≥ 40 s in men, but not in women. There were significant differences in the frequencies of metabolic abnormalities between subjects with airflow limitations and those without in women, but not in men. Smoking index was an independent factor associated with increased frequencies of hypertriglyceridemia (OR 1.015; 95% CI: 1.012–1.018; p<0.0001) and low high-density-lipoprotein cholesterolemia (1.013; 1.010–1.016; p<0.0001) in men. Length of smoking cessation was an independent factor associated with a decreased frequency of hypertriglyceridemia (0.984; 0.975–0.994; p = 0.007). CONCLUSIONS: Habitual smoking causes high incidences of airflow limitation and metabolic abnormalities. Women, but not men, with airflow limitation had higher frequencies of metabolic abnormalities. Public Library of Science 2013-11-29 /pmc/articles/PMC3843673/ /pubmed/24312268 http://dx.doi.org/10.1371/journal.pone.0081145 Text en © 2013 Horie et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Horie, Masafumi
Noguchi, Satoshi
Tanaka, Wakae
Goto, Yasushi
Yoshihara, Hisanao
Kawakami, Masaki
Suzuki, Masaru
Sakamoto, Yoshio
Relationships among Smoking Habits, Airflow Limitations, and Metabolic Abnormalities in School Workers
title Relationships among Smoking Habits, Airflow Limitations, and Metabolic Abnormalities in School Workers
title_full Relationships among Smoking Habits, Airflow Limitations, and Metabolic Abnormalities in School Workers
title_fullStr Relationships among Smoking Habits, Airflow Limitations, and Metabolic Abnormalities in School Workers
title_full_unstemmed Relationships among Smoking Habits, Airflow Limitations, and Metabolic Abnormalities in School Workers
title_short Relationships among Smoking Habits, Airflow Limitations, and Metabolic Abnormalities in School Workers
title_sort relationships among smoking habits, airflow limitations, and metabolic abnormalities in school workers
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843673/
https://www.ncbi.nlm.nih.gov/pubmed/24312268
http://dx.doi.org/10.1371/journal.pone.0081145
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