Mutational Analysis of Sclerostin Shows Importance of the Flexible Loop and the Cystine-Knot for Wnt-Signaling Inhibition

The cystine-knot containing protein Sclerostin is an important negative regulator of bone growth and therefore represents a promising therapeutic target. It exerts its biological task by inhibiting the Wnt (wingless and int1) signaling pathway, which participates in bone formation by promoting the d...

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Detalles Bibliográficos
Autores principales: Boschert, Verena, van Dinther, Maarten, Weidauer, Stella, van Pee, Katharina, Muth, Eva-Maria, ten Dijke, Peter, Mueller, Thomas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843708/
https://www.ncbi.nlm.nih.gov/pubmed/24312339
http://dx.doi.org/10.1371/journal.pone.0081710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843708/
https://www.ncbi.nlm.nih.gov/pubmed/24312339
http://dx.doi.org/10.1371/journal.pone.0081710

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