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Mutational Analysis of Sclerostin Shows Importance of the Flexible Loop and the Cystine-Knot for Wnt-Signaling Inhibition

The cystine-knot containing protein Sclerostin is an important negative regulator of bone growth and therefore represents a promising therapeutic target. It exerts its biological task by inhibiting the Wnt (wingless and int1) signaling pathway, which participates in bone formation by promoting the d...

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Detalles Bibliográficos
Autores principales:	Boschert, Verena, van Dinther, Maarten, Weidauer, Stella, van Pee, Katharina, Muth, Eva-Maria, ten Dijke, Peter, Mueller, Thomas D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843708/ https://www.ncbi.nlm.nih.gov/pubmed/24312339 http://dx.doi.org/10.1371/journal.pone.0081710

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