Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase

Long-term depression (LTD) reduces the functional strength of excitatory synapses through mechanisms that include the removal of AMPA glutamate receptors from the postsynaptic membrane. LTD induction is also known to result in structural changes at excitatory synapses, including the shrinkage of den...

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Detalles Bibliográficos
Autores principales: Lee, Hyejin, Lee, Eun-Jae, Song, Yoo Sung, Kim, Eunjoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2014
Materias:
Part III: Synaptic plasticity and brain disorders
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843889/
https://www.ncbi.nlm.nih.gov/pubmed/24298159
http://dx.doi.org/10.1098/rstb.2013.0158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843889/
https://www.ncbi.nlm.nih.gov/pubmed/24298159
http://dx.doi.org/10.1098/rstb.2013.0158

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