Small Molecules Enable Neurogenin 2 to Efficiently Convert Human Fibroblasts to Cholinergic Neurons

Cell fate can be reprogrammed by modifying intrinsic and extrinsic cues. Here, we show that two small molecules (forskolin and dorsomorphin) enable the transcription factor Neurogenin 2 (NGN2) to convert human fetal lung fibroblasts into cholinergic neurons with high purity (>90%) and efficiency...

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Detalles Bibliográficos
Autores principales: Liu, Meng-Lu, Zang, Tong, Zou, Yuhua, Chang, Joshua, Gibson, Jay, Huber, Kimberly M., Zhang, Chun-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843951/
https://www.ncbi.nlm.nih.gov/pubmed/23873306
http://dx.doi.org/10.1038/ncomms3183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843951/
https://www.ncbi.nlm.nih.gov/pubmed/23873306
http://dx.doi.org/10.1038/ncomms3183

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