Orthogonal Cas9 Proteins for RNA-Guided Gene Regulation and Editing

The Cas9 protein from the Streptococcus pyogenes CRISPR-Cas immune system has been adapted for both RNA-guided genome editing and gene regulation in a variety of organisms, but can mediate only a single activity at a time within any given cell. Here we characterize a set of fully orthogonal Cas9 pro...

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Detalles Bibliográficos
Autores principales: Esvelt, Kevin M., Mali, Prashant, Braff, Jonathan L., Moosburner, Mark, Yaung, Stephanie J., Church, George M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844869/
https://www.ncbi.nlm.nih.gov/pubmed/24076762
http://dx.doi.org/10.1038/nmeth.2681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844869/
https://www.ncbi.nlm.nih.gov/pubmed/24076762
http://dx.doi.org/10.1038/nmeth.2681

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