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Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences

The mammalian unfolded protein response (UPR) is propagated by three ER-resident transmembrane proteins, each of which initiates a signaling cascade that ultimately culminates in production of a transcriptional activator. The UPR was originally characterized as a pathway for upregulating ER chaperon...

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Detalles Bibliográficos
Autores principales: Arensdorf, Angela M., Diedrichs, Danilo, Rutkowski, D. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844873/
https://www.ncbi.nlm.nih.gov/pubmed/24348511
http://dx.doi.org/10.3389/fgene.2013.00256