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Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences

The mammalian unfolded protein response (UPR) is propagated by three ER-resident transmembrane proteins, each of which initiates a signaling cascade that ultimately culminates in production of a transcriptional activator. The UPR was originally characterized as a pathway for upregulating ER chaperon...

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Autores principales: Arensdorf, Angela M., Diedrichs, Danilo, Rutkowski, D. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844873/
https://www.ncbi.nlm.nih.gov/pubmed/24348511
http://dx.doi.org/10.3389/fgene.2013.00256
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author Arensdorf, Angela M.
Diedrichs, Danilo
Rutkowski, D. Thomas
author_facet Arensdorf, Angela M.
Diedrichs, Danilo
Rutkowski, D. Thomas
author_sort Arensdorf, Angela M.
collection PubMed
description The mammalian unfolded protein response (UPR) is propagated by three ER-resident transmembrane proteins, each of which initiates a signaling cascade that ultimately culminates in production of a transcriptional activator. The UPR was originally characterized as a pathway for upregulating ER chaperones, and a comprehensive body of subsequent work has shown that protein synthesis, folding, oxidation, trafficking, and degradation are all transcriptionally enhanced by the UPR. However, the global reach of the UPR extends to genes involved in diverse physiological processes having seemingly little to do with ER protein folding, and this includes a substantial number of mRNAs that are suppressed by stress rather than stimulated. Through multiple non-canonical mechanisms emanating from each of the UPR pathways, the cell dynamically regulates transcription and mRNA degradation. Here we highlight these mechanisms and their increasingly appreciated impact on physiological processes.
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spelling pubmed-38448732013-12-13 Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences Arensdorf, Angela M. Diedrichs, Danilo Rutkowski, D. Thomas Front Genet Endocrinology The mammalian unfolded protein response (UPR) is propagated by three ER-resident transmembrane proteins, each of which initiates a signaling cascade that ultimately culminates in production of a transcriptional activator. The UPR was originally characterized as a pathway for upregulating ER chaperones, and a comprehensive body of subsequent work has shown that protein synthesis, folding, oxidation, trafficking, and degradation are all transcriptionally enhanced by the UPR. However, the global reach of the UPR extends to genes involved in diverse physiological processes having seemingly little to do with ER protein folding, and this includes a substantial number of mRNAs that are suppressed by stress rather than stimulated. Through multiple non-canonical mechanisms emanating from each of the UPR pathways, the cell dynamically regulates transcription and mRNA degradation. Here we highlight these mechanisms and their increasingly appreciated impact on physiological processes. Frontiers Media S.A. 2013-12-02 /pmc/articles/PMC3844873/ /pubmed/24348511 http://dx.doi.org/10.3389/fgene.2013.00256 Text en Copyright © 2013 Arensdorf, Diedrichs and Rutkowski. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Arensdorf, Angela M.
Diedrichs, Danilo
Rutkowski, D. Thomas
Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences
title Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences
title_full Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences
title_fullStr Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences
title_full_unstemmed Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences
title_short Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences
title_sort regulation of the transcriptome by er stress: non-canonical mechanisms and physiological consequences
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844873/
https://www.ncbi.nlm.nih.gov/pubmed/24348511
http://dx.doi.org/10.3389/fgene.2013.00256
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