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Mouse models of Mdm2 and Mdm4 and their clinical implications

Mdm2 and Mdm4 are two key negative regulators of the tumor suppressor p53. Deletion of either Mdm2 or Mdm4 induces p53-dependent early embryonic lethality in knockout mouse models. The tissue-specific deletion of Mdm2 induces p53-dependent apoptosis, whereas the deletion of Mdm4 induces both p53-dep...

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Detalles Bibliográficos
Autor principal: Xiong, Shunbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sun Yat-sen University Cancer Center 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845603/
https://www.ncbi.nlm.nih.gov/pubmed/23327795
http://dx.doi.org/10.5732/cjc.012.10286