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Mouse models of Mdm2 and Mdm4 and their clinical implications
Mdm2 and Mdm4 are two key negative regulators of the tumor suppressor p53. Deletion of either Mdm2 or Mdm4 induces p53-dependent early embryonic lethality in knockout mouse models. The tissue-specific deletion of Mdm2 induces p53-dependent apoptosis, whereas the deletion of Mdm4 induces both p53-dep...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Sun Yat-sen University Cancer Center
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845603/ https://www.ncbi.nlm.nih.gov/pubmed/23327795 http://dx.doi.org/10.5732/cjc.012.10286 |