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Molecular mechanisms of tumor resistance to PI3K-mTOR-targeted therapy

Deregulation of the phosphatidylinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) signaling pathway occurs frequently in a wide range of human cancers and is a major driving force in tumorigenesis. Thus, small molecules targeting this pathway are under active development as anticanc...

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Detalles Bibliográficos
Autores principales: Tan, Jing, Yu, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sun Yat-sen University Cancer Center 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845604/
https://www.ncbi.nlm.nih.gov/pubmed/23668928
http://dx.doi.org/10.5732/cjc.012.10287