Estimation of the Fraction of Cancer Cells in a Tumor DNA Sample Using DNA Methylation

Contamination of normal cells is almost always present in tumor samples and affects their molecular analyses. DNA methylation, a stable epigenetic modification, is cell type-dependent, and different between cancer and normal cells. Here, we aimed to demonstrate that DNA methylation can be used to es...

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Detalles Bibliográficos
Autores principales: Takahashi, Takamasa, Matsuda, Yasunori, Yamashita, Satoshi, Hattori, Naoko, Kushima, Ryoji, Lee, Yi-Chia, Igaki, Hiroyasu, Tachimori, Yuji, Nagino, Masato, Ushijima, Toshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846724/
https://www.ncbi.nlm.nih.gov/pubmed/24312652
http://dx.doi.org/10.1371/journal.pone.0082302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846724/
https://www.ncbi.nlm.nih.gov/pubmed/24312652
http://dx.doi.org/10.1371/journal.pone.0082302

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