Assessing the translatability of In vivo cardiotoxicity mechanisms to In vitro models using causal reasoning

Drug-induced cardiac toxicity has been implicated in 31% of drug withdrawals in the USA. The fact that the risk for cardiac-related adverse events goes undetected in preclinical studies for so many drugs underscores the need for better, more predictive in vitro safety screens to be deployed early in...

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Detalles Bibliográficos
Autores principales: Enayetallah, Ahmed E, Puppala, Dinesh, Ziemek, Daniel, Fischer, James E, Kantesaria, Sheila, Pletcher, Mathew T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846863/
https://www.ncbi.nlm.nih.gov/pubmed/24010585
http://dx.doi.org/10.1186/2050-6511-14-46

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846863/
https://www.ncbi.nlm.nih.gov/pubmed/24010585
http://dx.doi.org/10.1186/2050-6511-14-46

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