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Assessing the translatability of In vivo cardiotoxicity mechanisms to In vitro models using causal reasoning
Drug-induced cardiac toxicity has been implicated in 31% of drug withdrawals in the USA. The fact that the risk for cardiac-related adverse events goes undetected in preclinical studies for so many drugs underscores the need for better, more predictive in vitro safety screens to be deployed early in...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846863/ https://www.ncbi.nlm.nih.gov/pubmed/24010585 http://dx.doi.org/10.1186/2050-6511-14-46 |