Phosphorylation of ASPP2 by RAS/MAPK Pathway Is Critical for Its Full Pro-Apoptotic Function

We reported recently that apoptosis-stimulating protein of p53 (ASPP) 2, an activator of p53, co-operates with oncogenic RAS to enhance the transcription and apoptotic function of p53. However, the detailed mechanism remains unknown. Here we show that ASPP2 is a novel substrate of mitogen-activated...

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Detalles Bibliográficos
Autores principales: Godin-Heymann, Nadia, Wang, Yihua, Slee, Elizabeth, Lu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847091/
https://www.ncbi.nlm.nih.gov/pubmed/24312625
http://dx.doi.org/10.1371/journal.pone.0082022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847091/
https://www.ncbi.nlm.nih.gov/pubmed/24312625
http://dx.doi.org/10.1371/journal.pone.0082022

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