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Identification of potential synthetic lethal genes to p53 using a computational biology approach

BACKGROUND: Identification of genes that are synthetic lethal to p53 is an important strategy for anticancer therapy as p53 mutations have been reported to occur in more than half of all human cancer cases. Although genome-wide RNAi screening is an effective approach to finding synthetic lethal gene...

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Detalles Bibliográficos
Autores principales: Wang, Xiaosheng, Simon, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847148/
https://www.ncbi.nlm.nih.gov/pubmed/24025726
http://dx.doi.org/10.1186/1755-8794-6-30