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Identification of potential synthetic lethal genes to p53 using a computational biology approach
BACKGROUND: Identification of genes that are synthetic lethal to p53 is an important strategy for anticancer therapy as p53 mutations have been reported to occur in more than half of all human cancer cases. Although genome-wide RNAi screening is an effective approach to finding synthetic lethal gene...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847148/ https://www.ncbi.nlm.nih.gov/pubmed/24025726 http://dx.doi.org/10.1186/1755-8794-6-30 |