Phenylketonuria: reduced tyrosine brain influx relates to reduced cerebral protein synthesis

BACKGROUND: In phenylketonuria (PKU), elevated blood phenylalanine (Phe) concentrations are considered to impair transport of large neutral amino acids (LNAAs) from blood to brain. This impairment is believed to underlie cognitive deficits in PKU via different mechanisms, including reduced cerebral...

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Detalles Bibliográficos
Autores principales: de Groot, Martijn J, Hoeksma, Marieke, Reijngoud, Dirk-Jan, de Valk, Harold W, Paans, Anne MJ, Sauer, Pieter JJ, van Spronsen, Francjan J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847152/
https://www.ncbi.nlm.nih.gov/pubmed/24007597
http://dx.doi.org/10.1186/1750-1172-8-133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847152/
https://www.ncbi.nlm.nih.gov/pubmed/24007597
http://dx.doi.org/10.1186/1750-1172-8-133

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