Dichloroacetate induces protective autophagy in LoVo cells: involvement of cathepsin D/thioredoxin-like protein 1 and Akt-mTOR-mediated signaling

Dichloroacetate (DCA) is an inhibitor of pyruvate dehydrogenase kinase (PDK), and recently it has been shown as a promising nontoxic antineoplastic agent. In this study, we demonstrated that DCA could induce autophagy in LoVo cells, which were confirmed by the formation of autophagosomes, appearance...

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Detalles Bibliográficos
Autores principales: Gong, F, Peng, X, Sang, Y, Qiu, M, Luo, C, He, Z, Zhao, X, Tong, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847316/
https://www.ncbi.nlm.nih.gov/pubmed/24201812
http://dx.doi.org/10.1038/cddis.2013.438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847316/
https://www.ncbi.nlm.nih.gov/pubmed/24201812
http://dx.doi.org/10.1038/cddis.2013.438

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