Cargando…

Dichloroacetate induces protective autophagy in LoVo cells: involvement of cathepsin D/thioredoxin-like protein 1 and Akt-mTOR-mediated signaling

Dichloroacetate (DCA) is an inhibitor of pyruvate dehydrogenase kinase (PDK), and recently it has been shown as a promising nontoxic antineoplastic agent. In this study, we demonstrated that DCA could induce autophagy in LoVo cells, which were confirmed by the formation of autophagosomes, appearance...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gong, F, Peng, X, Sang, Y, Qiu, M, Luo, C, He, Z, Zhao, X, Tong, A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847316/ https://www.ncbi.nlm.nih.gov/pubmed/24201812 http://dx.doi.org/10.1038/cddis.2013.438

Ejemplares similares

N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells
por: Wang, Min, et al.
Publicado: (2016)

Effects of ADMA on gene expression and metabolism in serum-starved LoVo cells
por: Zheng, Ningning, et al.
Publicado: (2016)

Laminarin-induced apoptosis in human colon cancer LoVo cells
por: JI, CHEN-FENG, et al.
Publicado: (2014)

Magnesium homeostasis in colon carcinoma LoVo cells sensitive or resistant to doxorubicin
por: Castiglioni, Sara, et al.
Publicado: (2015)

Transcriptome Analysis and Autophagy Investigation of LoVo Cells Stimulated with Exosomes Derived from T. asiatica Adult Worms
por: Liang, Panhong, et al.
Publicado: (2021)

Metformin suppressed the proliferation of LoVo cells and induced a time-dependent metabolic and transcriptional alteration
por: He, Jiaojiao, et al.
Publicado: (2015)

Alpha-2-Glycoprotein 1(AZGP1) Regulates Biological Behaviors of LoVo Cells by Down-Regulating mTOR Signaling Pathway and Endogenous Fatty Acid Synthesis
por: Chang, Ligong, et al.
Publicado: (2014)

Gene Expression Profile of the Human Colorectal Carcinoma LoVo Cells Treated With Sporamin and Thapsigargin
por: Yang, Chun, et al.
Publicado: (2021)

Butyrate modulates mucin secretion and bacterial adherence in LoVo cells via MAPK signaling
por: Jung, Tae-Hwan, et al.
Publicado: (2022)

Retraction: Alpha-2-Glycoprotein 1(AZGP1) Regulates Biological Behaviors of LoVo Cells by Down-Regulating mTOR Signaling Pathway and Endogenous Fatty Acid Synthesis
Publicado: (2019)

Effects of silencing RIP1 with siRNA on the biological behavior of the LoVo human colon cancer cell line
por: YOU, HONG-XIA, et al.
Publicado: (2014)

Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517).
por: Capolongo, L., et al.
Publicado: (1993)

pH-Sensitive Nanomicelles for Controlled and Efficient Drug Delivery to Human Colorectal Carcinoma LoVo Cells
por: Feng, Shi-Ting, et al.
Publicado: (2014)

Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells
por: Ohkubo, Shinji, et al.
Publicado: (2019)

ROS-Mediated Apoptotic Cell Death of Human Colon Cancer LoVo Cells by Milk δ-Valerobetaine
por: D’Onofrio, Nunzia, et al.
Publicado: (2020)

6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest
por: Lin, Ching-Bin, et al.
Publicado: (2012)

Ginsenoside-Rp1-induced apolipoprotein A-1 expression in the LoVo human colon cancer cell line
por: Kim, Mi-Yeon, et al.
Publicado: (2014)

In-Vitro and In-Silico Evaluations of Heterocyclic-Containing Diarylpentanoids as Bcl-2 Inhibitors Against LoVo Colorectal Cancer Cells
por: Leong, Sze Wei, et al.
Publicado: (2020)

Effects of Artonin E on Cell Growth Inhibition and Apoptosis Induction in Colon Cancer LoVo and HCT116 Cells
por: Yangnok, Kanyaluck, et al.
Publicado: (2022)

Network Pharmacology Analysis and Experiments Validation of the Inhibitory Effect of JianPi Fu Recipe on Colorectal Cancer LoVo Cells Metastasis and Growth
por: Lu, Xinyi, et al.
Publicado: (2020)

Effect of API-1 and FR180204 on cell proliferation and apoptosis in human DLD-1 and LoVo colorectal cancer cells
por: Saglam, Atiye Seda Yar, et al.
Publicado: (2016)

Overexpression of lamin B1 induces mitotic catastrophe in colon cancer LoVo cells and is associated with worse clinical outcomes
por: Izdebska, Magdalena, et al.
Publicado: (2017)

Microparticles vs. Macroparticles as Curcumin Delivery Vehicles: Structural Studies and Cytotoxic Effect in Human Adenocarcinoma Cell Line (LoVo)
por: Wezgowiec, Joanna, et al.
Publicado: (2021)

DDR1 promotes LoVo cell proliferation by regulatingenergy metabolism: Effect of DDR1 on CRC cell metabolic reprogramming
por: Xiong, Bin, et al.
Publicado: (2022)

Hederagenin from the leaves of ivy (Hedera helix L.) induces apoptosis in human LoVo colon cells through the mitochondrial pathway
por: Liu, Bao-Xin-Zi, et al.
Publicado: (2014)

Augmented O‐GlcNAcylation of AMP‐activated kinase promotes the proliferation of LoVo cells, a colon cancer cell line
por: Ishimura, Emi, et al.
Publicado: (2017)

Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation
por: Hsu, Hsi-Hsien, et al.
Publicado: (2017)

A new method for the study of biophysical and morphological parameters in 3D cell cultures: Evaluation in LoVo spheroids treated with crizotinib
por: Sargenti, Azzurra, et al.
Publicado: (2021)

A Comparison of Doxorubicin-Resistant Colon Cancer LoVo and Leukemia HL60 Cells: Common Features, Different Underlying Mechanisms
por: Locatelli, Laura, et al.
Publicado: (2021)

Synergistic antitumor effects of polysaccharides and anthocyanins from Lycium ruthenicum Murr. on human colorectal carcinoma LoVo cells and the molecular mechanism
por: Qin, Xinshu, et al.
Publicado: (2022)

Regulation of survivin and caspase/Bcl-2/Cyto-C signaling by TDB-6 induces apoptosis of colorectal carcinoma LoVo cells
por: Shi, Xianpeng, et al.
Publicado: (2022)

Dichloroacetate Overcomes Oxaliplatin Chemoresistance in Colorectal Cancer through the miR-543/PTEN/Akt/mTOR Pathway
por: Liang, Yu, et al.
Publicado: (2019)

Discoidin domain receptor 1a (DDR1a) confers 5-fluorouracil cytotoxicity in LoVo cell via PI3K/AKT/Bcl-2 pathway
por: Xiong, Bin, et al.
Publicado: (2022)

Different vimentin expression in two clones derived from a human colocarcinoma cell line (LoVo) showing different sensitivity to doxorubicin.
por: Conforti, G., et al.
Publicado: (1995)

Inhibition of protein kinase C-alpha isoform enhances the P-glycoprotein expression and the survival of LoVo human colon adenocarcinoma cells to doxorubicin exposure.
por: La Porta, C. A., et al.
Publicado: (1998)

Curcumol Inhibits Growth and Induces Apoptosis of Colorectal Cancer LoVo Cell Line via IGF-1R and p38 MAPK Pathway
por: Wang, Juan, et al.
Publicado: (2015)

Acetylshikonin Induces Apoptosis in Human Colorectal Cancer HCT-15 and LoVo Cells via Nuclear Translocation of FOXO3 and ROS Level Elevation
por: Lim, Heui Min, et al.
Publicado: (2021)

Prostaglandin E2-Induced COX-2 Expressions via EP2 and EP4 Signaling Pathways in Human LoVo Colon Cancer Cells
por: Hsu, Hsi-Hsien, et al.
Publicado: (2017)

Metformin and Dichloroacetate Suppress Proliferation of Liver Cancer Cells by Inhibiting mTOR Complex 1
por: Kim, Tae Suk, et al.
Publicado: (2021)

Downregulation of miR-222-3p Reverses Doxorubicin-Resistance in LoVo Cells Through Upregulating Forkhead Box Protein P2 (FOXP2) Protein
por: Wang, Huaiming, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_q0qtts7oll1sfve7doq040m85b