The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8

Apoptosis resistance is a hurdle for cancer treatment. HECTD3, a new E3 ubiquitin ligase, interacts with caspase-8 death effector domains and ubiquitinates caspase-8 with K63-linked polyubiquitin chains that do not target caspase-8 for degradation but decrease the caspase-8 activation. HECTD3 deplet...

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Detalles Bibliográficos
Autores principales: Li, Y, Kong, Y, Zhou, Z, Chen, H, Wang, Z, Hsieh, Y-C, Zhao, D, Zhi, X, Huang, J, Zhang, J, Li, H, Chen, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847339/
https://www.ncbi.nlm.nih.gov/pubmed/24287696
http://dx.doi.org/10.1038/cddis.2013.464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847339/
https://www.ncbi.nlm.nih.gov/pubmed/24287696
http://dx.doi.org/10.1038/cddis.2013.464

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