Shiga Toxin Type 2dact Displays Increased Binding to Globotriaosylceramide in vitro and Increased Lethality in Mice after Activation by Elastase

Shiga toxin type 2dact (Stx2dact), an Stx2 variant originally identified from Escherichia coli O91:H21 strain B2F1, displays increased cytotoxicity after activation by elastase present in intestinal mucus. Activation is a result of cleavage of two amino acids from the C-terminal tail of the A(2) sub...

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Detalles Bibliográficos
Autores principales: Bunger, Joshua C., Melton-Celsa, Angela R., O’Brien, Alison D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847715/
https://www.ncbi.nlm.nih.gov/pubmed/24217397
http://dx.doi.org/10.3390/toxins5112074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847715/
https://www.ncbi.nlm.nih.gov/pubmed/24217397
http://dx.doi.org/10.3390/toxins5112074

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