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Oats in the Diet of Children with Celiac Disease: Preliminary Results of a Double-Blind, Randomized, Placebo-Controlled Multicenter Italian Study

A gluten-free diet (GFD) is currently the only available treatment for patients with celiac disease (CD). Several clinical trials have demonstrated that most celiac patients can tolerate a medium-high quantity of oats without any negative clinical effects; however, the inclusion of oats in GFD is st...

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Autores principales: Gatti, Simona, Caporelli, Nicole, Galeazzi, Tiziana, Francavilla, Ruggiero, Barbato, Maria, Roggero, Paola, Malamisura, Basilio, Iacono, Giuseppe, Budelli, Andrea, Gesuita, Rosaria, Catassi, Carlo, Lionetti, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847754/
https://www.ncbi.nlm.nih.gov/pubmed/24264227
http://dx.doi.org/10.3390/nu5114653
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author Gatti, Simona
Caporelli, Nicole
Galeazzi, Tiziana
Francavilla, Ruggiero
Barbato, Maria
Roggero, Paola
Malamisura, Basilio
Iacono, Giuseppe
Budelli, Andrea
Gesuita, Rosaria
Catassi, Carlo
Lionetti, Elena
author_facet Gatti, Simona
Caporelli, Nicole
Galeazzi, Tiziana
Francavilla, Ruggiero
Barbato, Maria
Roggero, Paola
Malamisura, Basilio
Iacono, Giuseppe
Budelli, Andrea
Gesuita, Rosaria
Catassi, Carlo
Lionetti, Elena
author_sort Gatti, Simona
collection PubMed
description A gluten-free diet (GFD) is currently the only available treatment for patients with celiac disease (CD). Several clinical trials have demonstrated that most celiac patients can tolerate a medium-high quantity of oats without any negative clinical effects; however, the inclusion of oats in GFD is still a matter of debate. In this study, Italian children with CD were enrolled in a 15-month, randomized, double-blind, placebo-controlled multicenter trial. Participants were randomized in two groups following either A-B treatment (6 months of diet “A”, 3 months of standard GFD, 6 months of diet “B”), or B-A treatment (6 months of diet “B”, 3 months of standard GFD, 6 months of diet “A”). A and B diets included gluten-free (GF) products (flour, pasta, biscuits, cakes and crisp toasts) with either purified oats or placebo. Clinical data (Gastrointestinal Symptoms Rate Scale [GSRS] score) and intestinal permeability tests (IPT), were measured through the study period. Although the study is still blinded, no significant differences were found in GSRS score or the urinary lactulose/mannitol (L/M) ratio between the two groups after 6 months of treatment. These preliminary results suggest that the addition of non-contaminated oats from selected varieties in the treatment of children with CD does not determine changes in intestinal permeability and gastrointestinal symptoms.
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spelling pubmed-38477542013-12-03 Oats in the Diet of Children with Celiac Disease: Preliminary Results of a Double-Blind, Randomized, Placebo-Controlled Multicenter Italian Study Gatti, Simona Caporelli, Nicole Galeazzi, Tiziana Francavilla, Ruggiero Barbato, Maria Roggero, Paola Malamisura, Basilio Iacono, Giuseppe Budelli, Andrea Gesuita, Rosaria Catassi, Carlo Lionetti, Elena Nutrients Article A gluten-free diet (GFD) is currently the only available treatment for patients with celiac disease (CD). Several clinical trials have demonstrated that most celiac patients can tolerate a medium-high quantity of oats without any negative clinical effects; however, the inclusion of oats in GFD is still a matter of debate. In this study, Italian children with CD were enrolled in a 15-month, randomized, double-blind, placebo-controlled multicenter trial. Participants were randomized in two groups following either A-B treatment (6 months of diet “A”, 3 months of standard GFD, 6 months of diet “B”), or B-A treatment (6 months of diet “B”, 3 months of standard GFD, 6 months of diet “A”). A and B diets included gluten-free (GF) products (flour, pasta, biscuits, cakes and crisp toasts) with either purified oats or placebo. Clinical data (Gastrointestinal Symptoms Rate Scale [GSRS] score) and intestinal permeability tests (IPT), were measured through the study period. Although the study is still blinded, no significant differences were found in GSRS score or the urinary lactulose/mannitol (L/M) ratio between the two groups after 6 months of treatment. These preliminary results suggest that the addition of non-contaminated oats from selected varieties in the treatment of children with CD does not determine changes in intestinal permeability and gastrointestinal symptoms. MDPI 2013-11-20 /pmc/articles/PMC3847754/ /pubmed/24264227 http://dx.doi.org/10.3390/nu5114653 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Gatti, Simona
Caporelli, Nicole
Galeazzi, Tiziana
Francavilla, Ruggiero
Barbato, Maria
Roggero, Paola
Malamisura, Basilio
Iacono, Giuseppe
Budelli, Andrea
Gesuita, Rosaria
Catassi, Carlo
Lionetti, Elena
Oats in the Diet of Children with Celiac Disease: Preliminary Results of a Double-Blind, Randomized, Placebo-Controlled Multicenter Italian Study
title Oats in the Diet of Children with Celiac Disease: Preliminary Results of a Double-Blind, Randomized, Placebo-Controlled Multicenter Italian Study
title_full Oats in the Diet of Children with Celiac Disease: Preliminary Results of a Double-Blind, Randomized, Placebo-Controlled Multicenter Italian Study
title_fullStr Oats in the Diet of Children with Celiac Disease: Preliminary Results of a Double-Blind, Randomized, Placebo-Controlled Multicenter Italian Study
title_full_unstemmed Oats in the Diet of Children with Celiac Disease: Preliminary Results of a Double-Blind, Randomized, Placebo-Controlled Multicenter Italian Study
title_short Oats in the Diet of Children with Celiac Disease: Preliminary Results of a Double-Blind, Randomized, Placebo-Controlled Multicenter Italian Study
title_sort oats in the diet of children with celiac disease: preliminary results of a double-blind, randomized, placebo-controlled multicenter italian study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847754/
https://www.ncbi.nlm.nih.gov/pubmed/24264227
http://dx.doi.org/10.3390/nu5114653
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