Depletion of Luminal Pyridine Nucleotides in the Endoplasmic Reticulum Activates Autophagy with the Involvement of mTOR Pathway

It has been recently shown that redox imbalance of luminal pyridine nucleotides in the endoplasmic reticulum (ER) together with oxidative stress results in the activation of autophagy. In the present study we demonstrated that decrease of luminal NADPH/NADP(+) ratio alone by metyrapone was sufficien...

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Detalles Bibliográficos
Autores principales: Kapuy, Orsolya, Bánhegyi, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847967/
https://www.ncbi.nlm.nih.gov/pubmed/24350295
http://dx.doi.org/10.1155/2013/942431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847967/
https://www.ncbi.nlm.nih.gov/pubmed/24350295
http://dx.doi.org/10.1155/2013/942431

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