A transgenerational impact of siRNA on chromatin: siRNA amplification in Caenorhabditis elegans generates a homology-targeted footprint of H3K9 methylated nucleosomes

Exogenous double-stranded RNA (dsRNA) has been shown to exert homology-dependent effects at the level of both target mRNA stability and chromatin structure. Using C. elegans undergoing RNAi as an animal model, we have investigated the generality, scope, and longevity of chromatin-targeted dsRNA effe...

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Detalles Bibliográficos
Autores principales: Gu, Sam Guoping, Pak, Julia, Guang, Shouhong, Maniar, Jay M., Kennedy, Scott, Fire, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848608/
https://www.ncbi.nlm.nih.gov/pubmed/22231482
http://dx.doi.org/10.1038/ng.1039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848608/
https://www.ncbi.nlm.nih.gov/pubmed/22231482
http://dx.doi.org/10.1038/ng.1039

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