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A transgenerational impact of siRNA on chromatin: siRNA amplification in Caenorhabditis elegans generates a homology-targeted footprint of H3K9 methylated nucleosomes
Exogenous double-stranded RNA (dsRNA) has been shown to exert homology-dependent effects at the level of both target mRNA stability and chromatin structure. Using C. elegans undergoing RNAi as an animal model, we have investigated the generality, scope, and longevity of chromatin-targeted dsRNA effe...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848608/ https://www.ncbi.nlm.nih.gov/pubmed/22231482 http://dx.doi.org/10.1038/ng.1039 |