Phase II randomized, double-blind, placebo-controlled study of whole-brain irradiation with concomitant chloroquine for brain metastases

BACKGROUND AND PURPOSE: Chloroquine (CLQ), an antimalarial drug, has a lysosomotropic effect associated with increased radiationsensibility, which is mediated by the leakage of hydrolytic enzymes, increased apoptosis, autophagy and increased oxidative stress in vitro. In this phase II study, we eval...

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Detalles Bibliográficos
Autores principales: Rojas-Puentes, Luis L, Gonzalez-Pinedo, Marcelino, Crismatt, Alejando, Ortega-Gomez, Alette, Gamboa-Vignolle, Carlos, Nuñez-Gomez, Rodrigo, Dorantes-Gallareta, Yusmiren, Arce-Salinas, Claudia, Arrieta, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848663/
https://www.ncbi.nlm.nih.gov/pubmed/24010771
http://dx.doi.org/10.1186/1748-717X-8-209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848663/
https://www.ncbi.nlm.nih.gov/pubmed/24010771
http://dx.doi.org/10.1186/1748-717X-8-209

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