Accurate single nucleotide variant detection in viral populations by combining probabilistic clustering with a statistical test of strand bias

BACKGROUND: Deep sequencing is a powerful tool for assessing viral genetic diversity. Such experiments harness the high coverage afforded by next generation sequencing protocols by treating sequencing reads as a population sample. Distinguishing true single nucleotide variants (SNVs) from sequencing...

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Detalles Bibliográficos
Autores principales: McElroy, Kerensa, Zagordi, Osvaldo, Bull, Rowena, Luciani, Fabio, Beerenwinkel, Niko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848937/
https://www.ncbi.nlm.nih.gov/pubmed/23879730
http://dx.doi.org/10.1186/1471-2164-14-501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848937/
https://www.ncbi.nlm.nih.gov/pubmed/23879730
http://dx.doi.org/10.1186/1471-2164-14-501

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