Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum

BACKGROUND: Fatty acid synthase (FAS) is a promising antifungal target due to its marked structural differences between fungal and mammalian cells. The aim of this study was to evaluate the antifungal activity of flavonoids described in the scientific literature as FAS inhibitors (quercetin, trans-c...

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Detalles Bibliográficos
Autores principales: Bitencourt, Tamires Aparecida, Komoto, Tatiana Takahasi, Massaroto, Bruna Gabriele, Miranda, Carlos Eduardo Saraiva, Beleboni, Rene Oliveira, Marins, Mozart, Fachin, Ana Lúcia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849095/
https://www.ncbi.nlm.nih.gov/pubmed/24044691
http://dx.doi.org/10.1186/1472-6882-13-229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849095/
https://www.ncbi.nlm.nih.gov/pubmed/24044691
http://dx.doi.org/10.1186/1472-6882-13-229

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