A Simple Method for Assessing Free Brain/Free Plasma Ratios Using an In Vitro Model of the Blood Brain Barrier

Historically, the focus has been to use in vitro BBB models to optimize rate of drug delivery to the CNS, whereas total in vivo brain/plasma ratios have been used for optimizing extent. However, these two parameters do not necessarily show good correlations with receptor occupancy data or other phar...

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Detalles Bibliográficos
Autores principales: Culot, Maxime, Fabulas - da Costa, Anaëlle, Sevin, Emmanuel, Szorath, Erica, Martinsson, Stefan, Renftel, Mila, Hongmei, Yan, Cecchelli, Romeo, Lundquist, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849192/
https://www.ncbi.nlm.nih.gov/pubmed/24312489
http://dx.doi.org/10.1371/journal.pone.0080634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849192/
https://www.ncbi.nlm.nih.gov/pubmed/24312489
http://dx.doi.org/10.1371/journal.pone.0080634

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