L-Proline Induces a Mesenchymal-like Invasive Program in Embryonic Stem Cells by Remodeling H3K9 and H3K36 Methylation

Metabolites are emerging as key mediators of crosstalk between metabolic flux, cellular signaling, and epigenetic regulation of cell fate. We found that the nonessential amino acid L-proline (L-Pro) acts as a signaling molecule that promotes the conversion of embryonic stem cells into mesenchymal-li...

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Detalles Bibliográficos
Autores principales: Comes, Stefania, Gagliardi, Miriam, Laprano, Nicola, Fico, Annalisa, Cimmino, Amelia, Palamidessi, Andrea, De Cesare, Dario, De Falco, Sandro, Angelini, Claudia, Scita, Giorgio, Patriarca, Eduardo J., Matarazzo, Maria R., Minchiotti, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849245/
https://www.ncbi.nlm.nih.gov/pubmed/24319666
http://dx.doi.org/10.1016/j.stemcr.2013.09.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849245/
https://www.ncbi.nlm.nih.gov/pubmed/24319666
http://dx.doi.org/10.1016/j.stemcr.2013.09.001

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