TAL Effector Specificity for base 0 of the DNA Target Is Altered in a Complex, Effector- and Assay-Dependent Manner by Substitutions for the Tryptophan in Cryptic Repeat –1

TAL effectors are re-targetable transcription factors used for tailored gene regulation and, as TAL effector-nuclease fusions (TALENs), for genome engineering. Their hallmark feature is a customizable central string of polymorphic amino acid repeats that interact one-to-one with individual DNA bases...

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Detalles Bibliográficos
Autores principales: Doyle, Erin L., Hummel, Aaron W., Demorest, Zachary L., Starker, Colby G., Voytas, Daniel F., Bradley, Philip, Bogdanove, Adam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849474/
https://www.ncbi.nlm.nih.gov/pubmed/24312634
http://dx.doi.org/10.1371/journal.pone.0082120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849474/
https://www.ncbi.nlm.nih.gov/pubmed/24312634
http://dx.doi.org/10.1371/journal.pone.0082120

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