Cargando…

Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors

BACKGROUND: DNA damage response has been clearly described as an anti-cancer barrier in early human tumorigenesis. Moreover, interestingly, testicular germ cell tumors (TGCTs) have been reported to lack the DNA Damage Response (DDR) pathway activation. CCDC6 is a pro-apoptotic phosphoprotein substra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Staibano, Stefania, Ilardi, Gennaro, Leone, Vincenza, Luise, Chiara, Merolla, Francesco, Esposito, Francesco, Morra, Francesco, Siano, Maria, Franco, Renato, Fusco, Alfredo, Chieffi, Paolo, Celetti, Angela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849521/ https://www.ncbi.nlm.nih.gov/pubmed/24059746 http://dx.doi.org/10.1186/1471-2407-13-433

Ejemplares similares

Retraction Note: Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors
por: Staibano, Stefania, et al.
Publicado: (2021)

The tumour suppressor CCDC6 is involved in ROS tolerance and neoplastic transformation by evading ferroptosis
por: Morra, Francesco, et al.
Publicado: (2021)

CCDC6 and USP7 expression levels suggest novel treatment options in high-grade urothelial bladder cancer
por: Morra, Francesco, et al.
Publicado: (2019)

Identification of Sumoylation Sites in CCDC6, the First Identified RET Partner Gene in Papillary Thyroid Carcinoma, Uncovers a Mode of Regulating CCDC6 Function on CREB1 Transcriptional Activity
por: Luise, Chiara, et al.
Publicado: (2012)

FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC
por: Morra, Francesco, et al.
Publicado: (2015)

The combined effect of USP7 inhibitors and PARP inhibitors in hormone-sensitive and castration-resistant prostate cancer cells
por: Morra, Francesco, et al.
Publicado: (2017)

Ccdc6 knock-in mice develop thyroid hyperplasia associated to an enhanced CREB1 activity
por: Leone, Vincenza, et al.
Publicado: (2015)

Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage
por: Merolla, Francesco, et al.
Publicado: (2012)

The disruption of the CCDC6 – PP4 axis induces a BRCAness like phenotype and sensitivity to PARP inhibitors in high-grade serous ovarian carcinoma
por: Morra, Francesco, et al.
Publicado: (2022)

Overexpression of chromatin assembly factor-1 p60, poly(ADP-ribose) polymerase 1 and nestin predicts metastasizing behaviour of oral cancer
por: Mascolo, Massimo, et al.
Publicado: (2012)

CAF-1 Subunits Levels Suggest Combined Treatments with PARP-Inhibitors and Ionizing Radiation in Advanced HNSCC
por: Morra, Francesco, et al.
Publicado: (2019)

Epigenetic Disregulation in Oral Cancer
por: Mascolo, Massimo, et al.
Publicado: (2012)

Neuropilin-1 Expression Associates with Poor Prognosis in HNSCC and Elicits EGFR Activation upon CDDP-Induced Cytotoxic Stress
por: Napolitano, Virginia, et al.
Publicado: (2021)

miRNAs and Biomarkers in Testicular Germ Cell Tumors: An Update
por: De Martino, Marco, et al.
Publicado: (2021)

NSCLC Mutated Isoforms of CCDC6 Affect the Intracellular Distribution of the Wild Type Protein Promoting Cisplatinum Resistance and PARP Inhibitors Sensitivity in Lung Cancer Cells
por: Cerrato, Aniello, et al.
Publicado: (2019)

Tissue Microarray-Based Evaluation of Chromatin Assembly Factor-1 (CAF-1)/p60 as Tumour Prognostic Marker
por: Mascolo, Massimo, et al.
Publicado: (2012)

MAPK15 upregulation promotes cell proliferation and prevents DNA damage in male germ cell tumors
por: Rossi, Matteo, et al.
Publicado: (2016)

Tissue Expression of Carbonic Anhydrase IX Correlates to More Aggressive Phenotype of Basal Cell Carcinoma
por: Russo, Daniela, et al.
Publicado: (2021)

FKBP51 Immunohistochemical Expression: A New Prognostic Biomarker for OSCC?
por: Russo, Daniela, et al.
Publicado: (2017)

Histopathological Determinants of Tumor Resistance: A Special Look to the Immunohistochemical Expression of Carbonic Anhydrase IX in Human Cancers
por: Ilardi, G., et al.
Publicado: (2014)

A rare case of coexistence of metastasis from head and neck squamous cell carcinoma and tuberculosis within a neck lymph node
por: Caroppo, Danila, et al.
Publicado: (2015)

Probe-Based Confocal Laser Endomicroscopy Evaluation of Colon Preneoplastic Lesions, with Particular Attention to the Aberrant Crypt Foci, and Comparative Assessment with Histological Features Obtained by Conventional Endoscopy
por: Mascolo, Massimo, et al.
Publicado: (2012)

Epigenetics of oral and oropharyngeal cancers (Review)
por: Russo, Daniela, et al.
Publicado: (2020)

HPV Virus Transcriptional Status Assessment in a Case of Sinonasal Carcinoma
por: Ilardi, Gennaro, et al.
Publicado: (2018)

Expression of P16INK4a in Uveal Melanoma: New Perspectives
por: Russo, Daniela, et al.
Publicado: (2020)

The rationale for druggability of CCDC6-tyrosine kinase fusions in lung cancer
por: Cerrato, Aniello, et al.
Publicado: (2018)

Critical Function of PRDM2 in the Neoplastic Growth of Testicular Germ Cell Tumors
por: Di Zazzo, Erika, et al.
Publicado: (2016)

A Machine-learning Approach for the Assessment of the Proliferative Compartment of Solid Tumors on Hematoxylin-Eosin-Stained Sections
por: Martino, Francesco, et al.
Publicado: (2020)

Histopathological Image Deep Feature Representation for CBIR in Smart PACS
por: Tommasino, Cristian, et al.
Publicado: (2023)

Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic
por: Cerrato, Aniello, et al.
Publicado: (2016)

A xCT role in tumour-associated ferroptosis shed light on novel therapeutic options
por: Criscuolo, Daniela, et al.
Publicado: (2022)

The between Now and Then of Lung Cancer Chemotherapy and Immunotherapy
por: Visconti, Roberta, et al.
Publicado: (2017)

Overexpression of Chromatin Assembly Factor-1/p60 helps to predict the prognosis of melanoma patients
por: Mascolo, Massimo, et al.
Publicado: (2010)

Identification of Novel Biomarkers of Homologous Recombination Defect in DNA Repair to Predict Sensitivity of Prostate Cancer Cells to PARP-Inhibitors
por: Criscuolo, Daniela, et al.
Publicado: (2019)

Role of DNA repair machinery and p53 in the testicular germ cell cancer: a review
por: Romano, Francesco Jacopo, et al.
Publicado: (2016)

New combinatorial strategies to improve the PARP inhibitors efficacy in the urothelial bladder Cancer treatment
por: Criscuolo, Daniela, et al.
Publicado: (2019)

Testicular germ cell tumors
por: Albers, Peter
Publicado: (2021)

HMGA1-Regulating microRNAs Let-7a and miR-26a are Downregulated in Human Seminomas
por: De Martino, Marco, et al.
Publicado: (2020)

Germ Cell Neoplasia in situ (GCNIS) in Testis-Sparing Surgery (TSS) for Small Testicular Masses (STMs)
por: Pierconti, Francesco, et al.
Publicado: (2019)

The value of contrast-enhanced ultrasonography in the diagnosis of primary testicular non-neoplastic and neoplastic lesions in adults
por: Xue, Nianyu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_it6hldjsonpg7ralnou56edjve