Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes

BACKGROUND: The highly genetically diverse HIV-1 group M subtypes may differ in their biological properties. Nef is an important mediator of viral pathogenicity; however, to date, a comprehensive inter-subtype comparison of Nef in vitro function has not been undertaken. Here, we investigate two of N...

Descripción completa

Detalles Bibliográficos
Autores principales: Mann, Jaclyn K, Byakwaga, Helen, Kuang, Xiaomei T, Le, Anh Q, Brumme, Chanson J, Mwimanzi, Philip, Omarjee, Saleha, Martin, Eric, Lee, Guinevere Q, Baraki, Bemuluyigza, Danroth, Ryan, McCloskey, Rosemary, Muzoora, Conrad, Bangsberg, David R, Hunt, Peter W, Goulder, Philip JR, Walker, Bruce D, Harrigan, P Richard, Martin, Jeff N, Ndung’u, Thumbi, Brockman, Mark A, Brumme, Zabrina L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849644/
https://www.ncbi.nlm.nih.gov/pubmed/24041011
http://dx.doi.org/10.1186/1742-4690-10-100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849644/
https://www.ncbi.nlm.nih.gov/pubmed/24041011
http://dx.doi.org/10.1186/1742-4690-10-100

Ejemplares similares