Cargando…

Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes

BACKGROUND: The highly genetically diverse HIV-1 group M subtypes may differ in their biological properties. Nef is an important mediator of viral pathogenicity; however, to date, a comprehensive inter-subtype comparison of Nef in vitro function has not been undertaken. Here, we investigate two of N...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mann, Jaclyn K, Byakwaga, Helen, Kuang, Xiaomei T, Le, Anh Q, Brumme, Chanson J, Mwimanzi, Philip, Omarjee, Saleha, Martin, Eric, Lee, Guinevere Q, Baraki, Bemuluyigza, Danroth, Ryan, McCloskey, Rosemary, Muzoora, Conrad, Bangsberg, David R, Hunt, Peter W, Goulder, Philip JR, Walker, Bruce D, Harrigan, P Richard, Martin, Jeff N, Ndung’u, Thumbi, Brockman, Mark A, Brumme, Zabrina L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849644/ https://www.ncbi.nlm.nih.gov/pubmed/24041011 http://dx.doi.org/10.1186/1742-4690-10-100

Ejemplares similares

Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5
por: Jin, Steven W., et al.
Publicado: (2020)

No Evidence for Selection of HIV-1 with Enhanced Gag-Protease or Nef Function among Breakthrough Infections in the CAPRISA 004 Tenofovir Microbicide Trial
por: Chopera, Denis R., et al.
Publicado: (2013)

Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes
por: Umviligihozo, Gisele, et al.
Publicado: (2020)

HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity
por: Naicker, Delon, et al.
Publicado: (2023)

Naturally-arising amino acid polymorphisms of HIV-1 Nef that differentially modulate downregulation of HLA-A and HLA-B molecules
por: Mahiti, Macdonald, et al.
Publicado: (2013)

Attenuated HIV-1 Nef But Not Vpu Function in a Cohort of Rwandan Long-Term Survivors
por: Umviligihozo, Gisele, et al.
Publicado: (2022)

Genetic determinants of Nef-mediated CD4 and HLA class I down-regulation differences between HIV-1 subtypes B and C
por: Mann, Jaclyn K., et al.
Publicado: (2015)

Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences
por: Mahiti, Macdonald, et al.
Publicado: (2016)

Impairment of viral replication capacity by nef alleles from HIV elite controllers
por: Mwimanzi, Philip, et al.
Publicado: (2011)

Attenuation of multiple Nef functions in HIV-1 elite controllers
por: Mwimanzi, Philip, et al.
Publicado: (2013)

Longitudinal within-host evolution of HIV Nef-mediated CD4, HLA and SERINC5 downregulation activity: a case study
por: Sudderuddin, Hanwei, et al.
Publicado: (2020)

High Levels of Dual-Class Drug Resistance in HIV-Infected Children Failing First-Line Antiretroviral Therapy in Southern Ethiopia
por: Tadesse, Birkneh Tilahun, et al.
Publicado: (2018)

P09-09. Impact of immune-driven sequence variation in HIV-1 subtype C Gag-Protease on viral fitness and disease progression
por: Wright, JK, et al.
Publicado: (2009)

Differential evolution of a CXCR4-using HIV-1 strain in CCR5wt/wt and CCR5∆32/∆32 hosts revealed by longitudinal deep sequencing and phylogenetic reconstruction
por: Le, Anh Q., et al.
Publicado: (2015)

Prevalence and Correlates of Pre-Treatment HIV Drug Resistance among HIV-Infected Children in Ethiopia
por: Tadesse, Birkneh Tilahun, et al.
Publicado: (2019)

HLA-Associated Immune Escape Pathways in HIV-1 Subtype B Gag, Pol and Nef Proteins
por: Brumme, Zabrina L., et al.
Publicado: (2009)

Modelling and in vitro testing of the HIV-1 Nef fitness landscape
por: Barton, John P, et al.
Publicado: (2019)

Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag
por: Carlson, Jonathan M., et al.
Publicado: (2008)

Sociodemographic correlates of HIV drug resistance and access to drug resistance testing in British Columbia, Canada
por: Rocheleau, Genevieve, et al.
Publicado: (2017)

Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity
por: Jin, Steven W., et al.
Publicado: (2019)

Lack of a significant impact of Gag-Protease-mediated HIV-1 replication capacity on clinical parameters in treatment-naive Japanese individuals
por: Sakai, Keiko, et al.
Publicado: (2015)

Erratum to: Lack of a significant impact of Gag-Protease-mediated HIV-1 replication capacity on clinical parameters in treatment-naive Japanese individuals
por: Sakai, Keiko, et al.
Publicado: (2015)

Challenges and Opportunities for T-Cell-Mediated Strategies to Eliminate HIV Reservoirs
por: Brockman, Mark A., et al.
Publicado: (2015)

Progression to AIDS in South Africa Is Associated with both Reverting and Compensatory Viral Mutations
por: Huang, Kuan-Hsiang Gary, et al.
Publicado: (2011)

SARS-CoV-2 live virus neutralization after four COVID-19 vaccine doses in people with HIV receiving suppressive antiretroviral therapy
por: Cheung, Peter K., et al.
Publicado: (2023)

Theoretical and experimental assessment of degenerate primer tagging in ultra-deep applications of next-generation sequencing
por: Liang, Richard H., et al.
Publicado: (2014)

HIV reservoirs are dominated by genetically younger and clonally enriched proviruses
por: Kinloch, Natalie N., et al.
Publicado: (2023)

Impact of Pre-adapted HIV Transmission
por: Carlson, Jonathan M., et al.
Publicado: (2016)

Viral adaptation to immune selection pressure by HLA class I–restricted CTL responses targeting epitopes in HIV frameshift sequences
por: Berger, Christoph T., et al.
Publicado: (2010)

Limited Evolution of Inferred HIV-1 Tropism while Viremia Is Undetectable during Standard HAART Therapy
por: Lee, Guinevere Q., et al.
Publicado: (2014)

Statistical Resolution of Ambiguous HLA Typing Data
por: Listgarten, Jennifer, et al.
Publicado: (2008)

Nef-Specific CD8+ T Cell Responses Contribute to HIV-1 Immune Control
por: Adland, Emily, et al.
Publicado: (2013)

P09-10. Impact of CTL escape mutations in HIV-1 Nef on viral replication
por: Oniangue-Ndza, C, et al.
Publicado: (2009)

Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages
por: Mwimanzi, Philip, et al.
Publicado: (2011)

Concordance of HIV transmission risk factors elucidated using viral diversification rate and phylogenetic clustering
por: McLaughlin, Angela, et al.
Publicado: (2021)

The Fitness Landscape of HIV-1 Gag: Advanced Modeling Approaches and Validation of Model Predictions by In Vitro Testing
por: Mann, Jaclyn K., et al.
Publicado: (2014)

Human Leukocyte Antigen (HLA) Class I Down-Regulation by Human Immunodeficiency Virus Type 1 Negative Factor (HIV-1 Nef): What Might We Learn From Natural Sequence Variants?
por: Mwimanzi, Philip, et al.
Publicado: (2012)

Weak humoral immune reactivity among residents of long-term care facilities following one dose of the BNT162b2 mRNA COVID-19 vaccine
por: Brockman, Mark A., et al.
Publicado: (2021)

Detection of HIV transmission hotspots in British Columbia, Canada: A novel framework for the prioritization and allocation of treatment and prevention resources
por: McLaughlin, Angela, et al.
Publicado: (2019)

Rates and Correlates of Short Term Virologic Response among Treatment-Naïve HIV-Infected Children Initiating Antiretroviral Therapy in Ethiopia: A Multi-Center Prospective Cohort Study
por: Tadesse, Birkneh Tilahun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1e2l0cesblf65isfarred9huj9