Runx1 deficiency permits granulocyte lineage commitment but impairs subsequent maturation

First-hits in the multi-hit process of leukemogenesis originate in germline or hematopoietic stem cells (HSCs), yet leukemia-initiating cells (LICs) usually have a lineage-committed phenotype. The molecular mechanisms underlying this compartment shift during leukemia evolution have not been a major...

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Detalles Bibliográficos
Autores principales: Ng, K P, Hu, Z, Ebrahem, Q, Negrotto, S, Lausen, J, Saunthararajah, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849692/
https://www.ncbi.nlm.nih.gov/pubmed/24189977
http://dx.doi.org/10.1038/oncsis.2013.41

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849692/
https://www.ncbi.nlm.nih.gov/pubmed/24189977
http://dx.doi.org/10.1038/oncsis.2013.41

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