Molecular basis of telomere syndrome caused by CTC1 mutations

Mutations in CTC1 lead to the telomere syndromes Coats Plus and dyskeratosis congenita (DC), but the molecular mechanisms involved remain unknown. CTC1 forms with STN1 and TEN1 a trimeric complex termed CST, which binds ssDNA, promotes telomere DNA synthesis, and inhibits telomerase-mediated telomer...

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Detalles Bibliográficos
Autores principales: Chen, Liuh-Yow, Majerská, Jana, Lingner, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850094/
https://www.ncbi.nlm.nih.gov/pubmed/24115768
http://dx.doi.org/10.1101/gad.222893.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850094/
https://www.ncbi.nlm.nih.gov/pubmed/24115768
http://dx.doi.org/10.1101/gad.222893.113

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