Continuous 4–1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy

Co-stimulation through members of the tumor necrosis factor receptor (TNFR) family appears to be critical for the generation of T cells with optimal effector-memory properties for adoptive cell therapy. Our work suggests that continuous 4–1BB/CD137 co-stimulation is required for the expansion of T c...

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Detalles Bibliográficos
Autores principales: Chacon, Jessica Ann, Pilon-Thomas, Shari, Sarnaik, Amod A, Radvanyi, Laszlo G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850170/
https://www.ncbi.nlm.nih.gov/pubmed/24319633
http://dx.doi.org/10.4161/onci.25581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850170/
https://www.ncbi.nlm.nih.gov/pubmed/24319633
http://dx.doi.org/10.4161/onci.25581

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