Continuous 4–1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy

Co-stimulation through members of the tumor necrosis factor receptor (TNFR) family appears to be critical for the generation of T cells with optimal effector-memory properties for adoptive cell therapy. Our work suggests that continuous 4–1BB/CD137 co-stimulation is required for the expansion of T c...

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Autores principales: Chacon, Jessica Ann, Pilon-Thomas, Shari, Sarnaik, Amod A, Radvanyi, Laszlo G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850170/
https://www.ncbi.nlm.nih.gov/pubmed/24319633
http://dx.doi.org/10.4161/onci.25581
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author Chacon, Jessica Ann
Pilon-Thomas, Shari
Sarnaik, Amod A
Radvanyi, Laszlo G
author_facet Chacon, Jessica Ann
Pilon-Thomas, Shari
Sarnaik, Amod A
Radvanyi, Laszlo G
author_sort Chacon, Jessica Ann
collection PubMed
description Co-stimulation through members of the tumor necrosis factor receptor (TNFR) family appears to be critical for the generation of T cells with optimal effector-memory properties for adoptive cell therapy. Our work suggests that continuous 4–1BB/CD137 co-stimulation is required for the expansion of T cells with an optimal therapeutic profile and that the administration of 4–1BB agonists upon adoptive cell transfer further improves antitumor T-cell functions.
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spelling pubmed-38501702013-12-08 Continuous 4–1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy Chacon, Jessica Ann Pilon-Thomas, Shari Sarnaik, Amod A Radvanyi, Laszlo G Oncoimmunology Author's View Co-stimulation through members of the tumor necrosis factor receptor (TNFR) family appears to be critical for the generation of T cells with optimal effector-memory properties for adoptive cell therapy. Our work suggests that continuous 4–1BB/CD137 co-stimulation is required for the expansion of T cells with an optimal therapeutic profile and that the administration of 4–1BB agonists upon adoptive cell transfer further improves antitumor T-cell functions. Landes Bioscience 2013-09-01 2013-07-03 /pmc/articles/PMC3850170/ /pubmed/24319633 http://dx.doi.org/10.4161/onci.25581 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Chacon, Jessica Ann
Pilon-Thomas, Shari
Sarnaik, Amod A
Radvanyi, Laszlo G
Continuous 4–1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy
title Continuous 4–1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy
title_full Continuous 4–1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy
title_fullStr Continuous 4–1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy
title_full_unstemmed Continuous 4–1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy
title_short Continuous 4–1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy
title_sort continuous 4–1bb co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive t-cell therapy
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850170/
https://www.ncbi.nlm.nih.gov/pubmed/24319633
http://dx.doi.org/10.4161/onci.25581
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