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A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes
The tumor microenvironment is characterized by of high levels of extracellular nucleotides that are metabolized through the dynamic and sequential action of cell surface enzymes (ectoenzymes). These ectoenzymes operate according to their spatial arrangement, as part of (1) continuous (molecules on t...
Autores principales: | Horenstein, Alberto L, Chillemi, Antonella, Zaccarello, Gianluca, Bruzzone, Santina, Quarona, Valeria, Zito, Andrea, Serra, Sara, Malavasi, Fabio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850273/ https://www.ncbi.nlm.nih.gov/pubmed/24319640 http://dx.doi.org/10.4161/onci.26246 |
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