Large-scale multiple testing in genome-wide association studies via region-specific hidden Markov models

BACKGROUND: Identifying genetic variants associated with complex human diseases is a great challenge in genome-wide association studies (GWAS). Single nucleotide polymorphisms (SNPs) arising from genetic background are often dependent. The existing methods, i.e., local index of significance (LIS) an...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiao, Jian, Zhu, Wensheng, Guo, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850654/
https://www.ncbi.nlm.nih.gov/pubmed/24067069
http://dx.doi.org/10.1186/1471-2105-14-282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850654/
https://www.ncbi.nlm.nih.gov/pubmed/24067069
http://dx.doi.org/10.1186/1471-2105-14-282

Ejemplares similares