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Large-scale multiple testing in genome-wide association studies via region-specific hidden Markov models

BACKGROUND: Identifying genetic variants associated with complex human diseases is a great challenge in genome-wide association studies (GWAS). Single nucleotide polymorphisms (SNPs) arising from genetic background are often dependent. The existing methods, i.e., local index of significance (LIS) an...

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Detalles Bibliográficos
Autores principales:	Xiao, Jian, Zhu, Wensheng, Guo, Jianhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850654/ https://www.ncbi.nlm.nih.gov/pubmed/24067069 http://dx.doi.org/10.1186/1471-2105-14-282

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