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QT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development
Prolongation of the QT interval on the surface 12-lead electrocardiogram is widely accepted as a biomarker for the potential of a drug to produce torsades de pointes and/or sudden death. Detection of drug-induced prolongation of the QT interval in animals and man is frequently confounded by extrinsi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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IOS Press
2002
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851643/ https://www.ncbi.nlm.nih.gov/pubmed/12364811 http://dx.doi.org/10.1155/2002/482953 |
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author | Sides, Gregory D. |
author_facet | Sides, Gregory D. |
author_sort | Sides, Gregory D. |
collection | PubMed |
description | Prolongation of the QT interval on the surface 12-lead electrocardiogram is widely accepted as a biomarker for the potential of a drug to produce torsades de pointes and/or sudden death. Detection of drug-induced prolongation of the QT interval in animals and man is frequently confounded by extrinsic and intrinsic factors that limit the ability to detect a true drug effect. In particular drugs that increase heart rate show an apparent increase in QT interval that confounds assessment of a true drug effect on cardiac ventricular repolarization. The basis for the use of the QT interval as a biomarker will be examined. |
format | Online Article Text |
id | pubmed-3851643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38516432014-02-03 QT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development Sides, Gregory D. Dis Markers Other Prolongation of the QT interval on the surface 12-lead electrocardiogram is widely accepted as a biomarker for the potential of a drug to produce torsades de pointes and/or sudden death. Detection of drug-induced prolongation of the QT interval in animals and man is frequently confounded by extrinsic and intrinsic factors that limit the ability to detect a true drug effect. In particular drugs that increase heart rate show an apparent increase in QT interval that confounds assessment of a true drug effect on cardiac ventricular repolarization. The basis for the use of the QT interval as a biomarker will be examined. IOS Press 2002 2002-10-21 /pmc/articles/PMC3851643/ /pubmed/12364811 http://dx.doi.org/10.1155/2002/482953 Text en Copyright © 2002 Hindawi Publishing Corporation. |
spellingShingle | Other Sides, Gregory D. QT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development |
title | QT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development |
title_full | QT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development |
title_fullStr | QT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development |
title_full_unstemmed | QT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development |
title_short | QT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development |
title_sort | qt interval prolongation as a biomarker for torsades de pointes and sudden death in drug development |
topic | Other |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851643/ https://www.ncbi.nlm.nih.gov/pubmed/12364811 http://dx.doi.org/10.1155/2002/482953 |
work_keys_str_mv | AT sidesgregoryd qtintervalprolongationasabiomarkerfortorsadesdepointesandsuddendeathindrugdevelopment |