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QT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development

Prolongation of the QT interval on the surface 12-lead electrocardiogram is widely accepted as a biomarker for the potential of a drug to produce torsades de pointes and/or sudden death. Detection of drug-induced prolongation of the QT interval in animals and man is frequently confounded by extrinsi...

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Detalles Bibliográficos
Autor principal: Sides, Gregory D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851643/
https://www.ncbi.nlm.nih.gov/pubmed/12364811
http://dx.doi.org/10.1155/2002/482953
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author Sides, Gregory D.
author_facet Sides, Gregory D.
author_sort Sides, Gregory D.
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description Prolongation of the QT interval on the surface 12-lead electrocardiogram is widely accepted as a biomarker for the potential of a drug to produce torsades de pointes and/or sudden death. Detection of drug-induced prolongation of the QT interval in animals and man is frequently confounded by extrinsic and intrinsic factors that limit the ability to detect a true drug effect. In particular drugs that increase heart rate show an apparent increase in QT interval that confounds assessment of a true drug effect on cardiac ventricular repolarization. The basis for the use of the QT interval as a biomarker will be examined.
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spelling pubmed-38516432014-02-03 QT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development Sides, Gregory D. Dis Markers Other Prolongation of the QT interval on the surface 12-lead electrocardiogram is widely accepted as a biomarker for the potential of a drug to produce torsades de pointes and/or sudden death. Detection of drug-induced prolongation of the QT interval in animals and man is frequently confounded by extrinsic and intrinsic factors that limit the ability to detect a true drug effect. In particular drugs that increase heart rate show an apparent increase in QT interval that confounds assessment of a true drug effect on cardiac ventricular repolarization. The basis for the use of the QT interval as a biomarker will be examined. IOS Press 2002 2002-10-21 /pmc/articles/PMC3851643/ /pubmed/12364811 http://dx.doi.org/10.1155/2002/482953 Text en Copyright © 2002 Hindawi Publishing Corporation.
spellingShingle Other
Sides, Gregory D.
QT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development
title QT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development
title_full QT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development
title_fullStr QT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development
title_full_unstemmed QT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development
title_short QT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development
title_sort qt interval prolongation as a biomarker for torsades de pointes and sudden death in drug development
topic Other
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851643/
https://www.ncbi.nlm.nih.gov/pubmed/12364811
http://dx.doi.org/10.1155/2002/482953
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