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Deep mutational scanning of an RRM domain of the Saccharomyces cerevisiae poly(A)-binding protein
The RNA recognition motif (RRM) is the most common RNA-binding domain in eukaryotes. Differences in RRM sequences dictate, in part, both RNA and protein-binding specificities and affinities. We used a deep mutational scanning approach to study the sequence-function relationship of the RRM2 domain of...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851721/ https://www.ncbi.nlm.nih.gov/pubmed/24064791 http://dx.doi.org/10.1261/rna.040709.113 |