B-cell translocation gene 2 mediates crosstalk between PI3K/Akt1 and NFκB pathways which enhances transcription of MnSOD by accelerating IκBα degradation in normal and cancer cells

BACKGROUND: B-cell translocation gene 2 (BTG2) belongs to antiproliferative (ARPO) gene family and the expression of BTG2, human ortholog of rat PC3 and mouse TIS21 gene, has been shown to render cancer cells more sensitive to doxorubicin treatment by upregulating MnSOD expression without regulating...

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Detalles Bibliográficos
Autores principales: Sundaramoorthy, Santhoshkumar, Ryu, Min Sook, Lim, In Kyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851984/
https://www.ncbi.nlm.nih.gov/pubmed/24047462
http://dx.doi.org/10.1186/1478-811X-11-69

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851984/
https://www.ncbi.nlm.nih.gov/pubmed/24047462
http://dx.doi.org/10.1186/1478-811X-11-69

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