Estimation of feasible solution space using Cluster Newton Method: application to pharmacokinetic analysis of irinotecan with physiologically-based pharmacokinetic models

BACKGROUND: To facilitate new drug development, physiologically-based pharmacokinetic (PBPK) modeling methods receive growing attention as a tool to fully understand and predict complex pharmacokinetic phenomena. As the number of parameters to reproduce physiological functions tend to be large in PB...

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Detalles Bibliográficos
Autores principales: Yoshida, Kenta, Maeda, Kazuya, Kusuhara, Hiroyuki, Konagaya, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852065/
https://www.ncbi.nlm.nih.gov/pubmed/24555857
http://dx.doi.org/10.1186/1752-0509-7-S3-S3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852065/
https://www.ncbi.nlm.nih.gov/pubmed/24555857
http://dx.doi.org/10.1186/1752-0509-7-S3-S3

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