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Estimation of feasible solution space using Cluster Newton Method: application to pharmacokinetic analysis of irinotecan with physiologically-based pharmacokinetic models
BACKGROUND: To facilitate new drug development, physiologically-based pharmacokinetic (PBPK) modeling methods receive growing attention as a tool to fully understand and predict complex pharmacokinetic phenomena. As the number of parameters to reproduce physiological functions tend to be large in PB...
Autores principales: | Yoshida, Kenta, Maeda, Kazuya, Kusuhara, Hiroyuki, Konagaya, Akihiko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852065/ https://www.ncbi.nlm.nih.gov/pubmed/24555857 http://dx.doi.org/10.1186/1752-0509-7-S3-S3 |
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